This phenomenon is named the Paxlovid rebound. What precisely is that this, and why does it occur? How frequent is it, and does the potential for recurrence of signs imply that individuals mustn’t take it? Who ought to take the drugs and who mustn’t take it? And what do you have to do you probably have a recurrence?
Dr. Lena Wayne: The phenomenon known as Paxlovid rebound occurs when someone with Covid-19 takes the Paxlovid antiviral pill and begins to recover – their symptoms improve, and they begin to test negative. Then, usually within two weeks of their initial diagnosis, their symptoms recur, and they test positive for the coronavirus again. In President Joe Biden’s case, he was being tested regularly, so even if his symptoms did not recur, his positive test was picked up immediately.
Paxlovid works by stopping the viral replication. At present it is given for five days. Maybe it works for a period of five days, but some people still have the virus in their bodies after five days. When Paxlovid is stopped, the virus starts replicating again.
It is possible that Paxlovid may need to be given for a longer time – perhaps seven or 10 days instead of five days. Those studies are ongoing.
CNN: It looks like a lot of people, including President Biden and Dr. Anthony Fauci, have a PaxLovid rebound. How common is this?
Wayne: Anecdotally, we may know many people who have had it, but studies show that it is very uncommon.
Of course, the actual rate may be higher, as people are not being tested regularly after taking Paxlovid. As a result some cases may be left out. However, it still seems that the Paxlovid rebound is happening in a minority, not a majority of cases.
CNN: Does the potential for recurrence of symptoms mean people shouldn’t take it?
Wayne: No. I feel individuals ought to take into account the potential of rebound paxlovid as a recognized facet impact of the drug. Given the inconvenience of getting signs over and over, it’s actually not most well-liked. However, the potential of this facet impact is just not a cause to keep away from a drug that’s extremely efficient in decreasing extreme illness.
CNN: Who is eligible for PaxLovid? Are there people who shouldn’t take it?
As far as people who should not take it, Paxlovid is intended for individuals at high risk for serious illness. If you are under 50 years old, up to date with vaccines and generally healthy, you should not take it. Every drug is about weighing the risks and benefits. If you are unlikely to benefit, the risks will outweigh the benefits.
CNN: What should you do if you have a recurrence – do you take paxlovid again, and do you need to be isolated?
Taking precautions is the best strategy, however I wish to emphasize once more that the prospect of a relapse does not deter individuals from looking for the sort of remedy it is doing, which retains individuals out of hospital and making them significantly sick. To save from.